The Next Layer of Precision Medicine
Genomics tells us what could happen. Gene expression shows what is being expressed. RNA modifications add a dynamic regulatory layer, revealing how transcripts are controlled as cell state, disease, and treatment response change.
AlidaBio makes this layer measurable at scale, with integrated profiling of m6A, inosine, pseudouridine, and RNA expression in one workflow.
The Next Layer of Precision Medicine
Genomics tells us what could happen. Gene expression shows what is being expressed. RNA modifications add a dynamic regulatory layer, revealing how transcripts are controlled as cell state, disease, and treatment response change.
AlidaBio makes this layer measurable at scale, with integrated profiling of m6A, inosine, pseudouridine, and RNA expression in one workflow.
The Epitranscriptome Reveals what Other Omics Miss
Critical transitions in biology—from immune activation and tumor plasticity to stress response and acquired resistance—can occur without changes to DNA sequence and may not be fully captured by RNA abundance alone.
RNA modifications provide an additional functional readout of cellular state. By measuring them alongside gene expression in real-world clinical samples, AlidaBio enables researchers and partners to discover signatures linked to disease biology, treatment response, and patient stratification.
Applications Across Disease, Diagnostics, and Therapeutics
RNA modifications regulate transcript stability, translation, and processing. Profiling them alongside gene expression can reveal functional biology that expression measurements alone may not capture.
Biomarker Discovery and Translational Research
Add a dynamic molecular layer to biomarker discovery and translational studies.
- Discover signatures associated with cellular activity and disease state
- Characterize molecular responses to therapeutic intervention and disease progression
- Identify candidate signatures for patient stratification
AI and Multimodal Foundation Models
Foundational models require rich molecular data to learn the regulatory principles underlying cellular behavior.
- Add RNA modification information as a new biological feature layer for model training
- Improve prediction of cell state, regulatory responses, and molecular phenotypes
- Enable models that integrate genomic, transcriptomic, and epitranscriptomic information
Cancer Cell State and Therapy Response
Tumors evolve through dynamic changes in cellular state that contribute to heterogeneity and acquired resistance.
- Track transitions such as dedifferentiation and therapy resistance
- Study regulatory mechanisms underlying tumor heterogeneity
- Discover biomarkers linked to treatment response
Immune Cell Activation and Exhaustion
RNA modifications provide rapid, post-transcriptional control of immune responses.
- Resolve activation states not fully explained by transcription (Predict cell fitness in cell therapy)
- Study T cell exhaustion, cytokine signaling, and immune modulation
- Identify functional biomarkers of immune response
The Power of EpiPlex
RNA modifications and gene expression. Real world samples. One integrated platform.
EpiPlex uses molecular encoding during library preparation to convert RNA modifications into sequencing-detectable signals while measuring standard RNA-seq expression. It works with low RNA input (20 ng polyA RNA or 250 ng total RNA), clinical and degraded samples including FFPE and RNA from liquid biopsy. EpiScout makes it easy to move from raw sequencing data to the identification of genes and pathways most differentially modified at the RNA level.
Turnkey Profiling
Uni-Mod, Duo-Mod, or Tri-Mod services. Send samples, receive EpiScout™ results.
RNA modifications in biology and disease
Alida Biosciences’ technologies are designed to unleash the transformative potential of epitranscriptomics in basic research and applications in RNA-centered diagnostics and therapeutics. Proximity barcoding translates sequencing-silent RNA modifications into NGS-readable barcodes
Recent Media and Blog Posts
Pseudouridine: Minor Isomer, Major Consequences for RNA Function
Pseudouridine: Minor Isomer, Major Consequences for RNA Function Pseudouridine is the most abundant RNA modification and one of the most...
Alida Biosciences Launches EpiPlex® Tri-Mod™ Service for Simultaneous Profiling of Three Key mRNA Modifications
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STORM Therapeutics and AlidaBio Announce Strategic Collaboration to Accelerate Development of Cancer Therapies Targeting RNA Modifications
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Beyond Transcriptomics: RNA Modifications Shape Cancer Progression
RNA modifications such as m6A, A-to-I editing, and pseudouridine influence RNA stability, translation, splicing, and immune recognition. This article explains...
Beyond the Genome – The Story of Epitranscriptomics
In this insightful interview, Byron Purse (Alida Biosciences co-founder) and Pete Dedon (MIT) dive into the growing impact of...
AlidaBio Introduces the EpiPlex™ Duo-Mod™ Service for Concurrent m6A and Inosine Mapping with Integrated RNA Expression Profiling
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RNA Secrets Unveiled: Byron Purse’s Biotech Breakthrough Journey
In this episode of the Life Science Success podcast, Dr. Don Davis talks with Dr. Byron Purse, professor of chemistry...
EpiPlex™ Technology in Action
Share this post on LinkedIn The EpiPlex™ Platform delivers a streamlined, end-to-end workflow for high-resolution detection and relative...
The Power of Inosine: How RNA Editing Shapes the Transcriptome
Author: Zachary Miles Senior Director of Protein Engineering Share this post on LinkedIn One of the most transformative post-transcriptional modifications...
The EpiPlex™ Platform for Multi-Target Detection of RNA Modifications
Share this post on LinkedIn Dr. Gudrun Stengel, CEO and co-founder of Alida Biosciences, introduces the role of RNA modifications...
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